©Stepanenko,R.,Konovalova,T.&Stepanenko,V.TheclosecontactofTLR2-positive macrophagesisobservedinthesubepithelialsiteswithpositivelycoloreddendriticcells ofepidermis,thereby,theexpressionofmarkerintheseareaswasobservedinepithelial cells across the whole width of the layer up to the horny layer. The mentioned structural peculiarities may testify to activation of macrophages by dendritic cells of epidermis, which bind and concentrate the corresponding ligands. The analogous changes were found at study of TLR4 expression. The significant amount of TLR4 – positive dendritic cells,whichhadconsiderablylargersizesandwerespreadwiththeirappendicesupto the horny layer, was found in epidermis even after performed treatment. Hereby rather intensive background cytoplasmic coloration of those cells was observed. It should be mentionedthatthecoloniesofmicroorganismswereobservedinthehornyscalesofthe skin.

Pharmacist’s professional competence structure grounded (motivational and axiological, cognitive, professional and active, social and personal components); the content, forms and methods of forming social and personal, motivational and axiological components of pharmacist’s professional competence defined by integrating value-meaning, socially meaningful and professionally-oriented information into the program of relevant academic subjects and the extracurricular community services of the future pharmacists’; criteria of the formation of pharmacist’s professional competence outlined (axiological and motivational, cognitive, professional and active, social and personal); professional and personal rating of the future pharmacist grounded as an pedagogical technology of the professional competence formation; experimentally verified the effectiveness of the proposed content, forms and methods of the future pharmacists’ professional competence formation.

Diffusive clearance depends on blood (Qb) and dialysate flow (Qd) rates and the overall mass transfer area coefficient (KoA) of the dialyzer. In this article we describe a model to predict an appropriated AutoFlow factor (AF=Ratio Qd/Qb), that is able to provide adequate Kt/V for haemodialysis patients (HDP) , while consuming lower amounts of dialysate, water and energy during the treatment.